Table 1.

Exosomal miRNA detected in serum or plasma of BC patients that could be useful for early diagnosis.

miRNA	Special Characteristics	References
miR-21 and mi-R1246	Significantly high in BC although ubiquitous in human exosomes	Hannafon et al. [78]
miR-145, miR-155 and miR-382	Significantly high in BC although ubiquitous in human exosomes	Gonzalez-Villasana et al. [83]
miR-101 and miR-372	Significantly high in BC	Eichelser et al. [84]
miR-223-3p	Significantly high in BC	Yoshikawa et al. [85]
miR-16	Significantly high in BC, especially if estrogen-positive	Ni et al. [86]
miR-93	Significantly high in DCIS	Ni et al. [86]
miR-188-3p, miR-500a-5p and miR-502-3p (miR-532-502 cluster)	Significantly high in BC	Zou et al. [87]
miR-122-5p	Significantly high in BC	Li et al. [88]
miR-106a-3p, miR-106a-5p, miR-92a-2-5p, miR-19b-3p and miR-92a-3p (miR-106a-363 cluster)	Significantly high in BC	Li et al. [89]
let-7b-5p, miR-106a-5p, miR-19a-3p, miR-19b-3p, miR-25-3p, miR-425-5p, miR-451a, miR-92a-3p, miR-93-5p and miR-16-5p	Significantly high in BC	Zou et al. [90]
miR-148a	Significantly downregulated in BC	Li et al. [92]
miR-27a/b, miR-30c, miR-150, miR-152, miR-199a-3p, miR-340, miR-376a, miR-410 and miR-598	Significantly deregulated in BC	Stevic et al. [96]
miR-21 and miR-105	Significantly high in metastatic vs. localized BC	Rodriguez-Martinez et al. [93]
miR-373	Significantly high in TNBC	Eichelser et al. [84]
miR-222	Significantly high in TNBC and luminal B vs. luminal A BC	Rodriguez-Martinez et al. [93]
miR-27b, miR-30c, miR-128a, miR-145, miR-150, miR-152, miR-199a-3p, miR-324-3p, miR-335, miR-340, miR-376a/c, miR-382, miR-410, miR-423-5p, miR-433 and miR-598	Significantly deregulated in TNBC	Stevic et al. [96]
miR-27a/b, miR-30c, miR-150, miR-152, miR-199a-3p, miR-328, miR-340, miR-365, miR-410, miR-422a, miR-598 and miR-628	Significantly deregulated in HER2-positive BC	Stevic et al. [96]