Figure 5.

Quantitative analysis of the number of cortical (a) and hippocampal (d) amyloid-β (Aβ) plaques (n) per high-power field (HPF) and the cortical (b) and hippocampal (e) Aβ-plaque area (µm²) of wild-type (wt; not detectable n.d.) and transgenic APPswe/PS1delta9 (tg) mice and representative immunohistochemical images of cortical (scale bar representing 50 µm (c)) and hippocampal (scale bar representing 100 µm (f)) Aβ-stained (6E10) brain sections of tg mice. Mice were fed either ad libitum (AL) or a caloric-restricted diet (CR, 60% of ad libitum) for 68 weeks. Significance of differences between the groups was tested by unpaired student t-test, followed by Bonferroni correction with p threshold of 0.0166: *** p ≤ 0.001 vs. AL.