Table 1.

Genetic characteristics of T-VEC construct. GM-CSF: Granulocyte-macrophage colony-stimulating factor; HSV-1: Herpes simplex virus type 1. US11: Unique short glycoprotein 11.

T-VEC Genetic Components	Conferred Function
HSV-1 JS1	promotes preferential viral targeting of tumor cells
ICP34.5 gene deletion	Attenuates the natural viral pathogenicity allowing the virus to replicate selectively in tumor cells
ICP47 gene deletion	Reduces virally mediated suppression of antigen presentation and increase the expression of the HSV US11 gene
HSV US11 gene	Promotes virus growth in tumor cells without impairing tumor selectivity
GM-CSF cassette insertion	GM-CSF expression increases the recruitment of antigen-presenting cells and triggers a systemic antitumor immune response