Table 1.
The Aβ monomer aggregation inhibitory capability of compounds 1–6 a.
Compound | Plateau Reduction (% Inhibition) |
Lag Time Extension (Fold Increase) |
---|---|---|
1 | N.E. | 2.8 ± 0.6 |
2 | N.E. | N.E. |
3 | 60.9% ± 5.7% | N.E. |
4 | N.E. | N.E. |
5 | 39.1% ± 19.2% | 2.0 ± 0.6 |
6 | 71.8% ± 3.9% | N.E. |
The observed plateau or lag time in the presence of 100 µM compound is not significantly different from that observed for control samples. a Inhibitions are expressed as mean ± SEM, n = 3–5.