Table 1.
miR-29a and HCC carcinogenesis. List of the roles and mechanisms of miR-29a in carcinogenesis: stemness, apoptosis, proliferation, and HBV dissemination.
| Role of miR-29a | Involved Mechanism | Used Model | Target Gene | Pathway | Outcome | Reference |
|---|---|---|---|---|---|---|
| − | Stemness, apoptosis | CSC | BCL-2 | ↑miR-29a →↓BCL-2 |
↓CSC self renewal ↑Sorafenib response ↓PDX growth |
[46] |
| − | Apoptosis | SMMC7721 and Hep3B cells | MDM2 | ↑XPD→↑miR-29a →↓MDM2→↑p53 |
↓Proliferation ↓Migration |
[45] |
| − | Apoptosis | Hep3B, HepG2 cells; Xenograft mice; Human HCC tissue |
MCL1 | Mutant ATCB →↓miR-29a →↑MCL1 |
↑Proliferation ↑Migration ↑Invasion ↑Tumor growth |
[47] |
| − | Proliferation | SMMC7721 and Hep3B cells | PDGFB | ↑XPD→↑miR-29a →↓PDGFB |
↓Proliferation ↓Migration |
[45] |
| + | HBsAg dissemination | HepG2 cell | SMARCE1 | ↑miR-29a →↓SMARCE1 →↑HBsAg |
↑HBV replication | [44] |
| + | Proliferation | HepG2 and HepG2-X cell | PTEN | ↑HBx →↑miR-29a →↓PTEN →↑p-AKT |
↑Migration | [43] |
“+”, pro-HCC effect; “−”, anti-HCC effect; “↑”, enhanced; “↓”, reduced; “→”, leading to a particular event; CLDN1, claudin1; CSC, cancer stem cells; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HBx, Hepatitis B virus X protein; MEG3, maternally expressed 3; PDGFB, platelet-derived growth factor subunit B; PTEN, phosphatase and tensin homolog; SMARCE1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; XPD, Xeroderma pigmentosum D.