Table 1.
Inhibitors of 2-OG Enzymes.
| Inhibitor | Target Protein(s) | Disease Context | References |
|---|---|---|---|
| GSK1278863 | PHDs | Anemia of chronic kidney disease | [220] |
| FG-4592 | PHDs | Anemia of chronic kidney disease | [221] |
| Fisetin | TET1 | Renal cancer stem cells | [222] |
| Compound 10 and 13 | KDM5 | Lung cancer cell line A549 | [223] |
| NCDM-32B | KDM4 | Basal-like breast cancer | [224] |
| IOX1 | KDM3, KDM4 | Colorectal cancer and vascular smooth muscle cells in atherosclerosis | [225,226] |
| GSK2879552 | KDM1A | Small cell lung carcinoma | [227] |
| FB23 and FB23-2 | FTO | Acute myeloid leukemia | [228] |
| Compound 7l | ALKBH3 | Prostate cancer cell line DU145 | [229] |
| Indenone derivative Compound 5c | ALKBH3 | Lung cancer cell line A549 | [230] |