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Synthesis of nopol-derived 1,3,4-thiadiazole-thiourea compounds 6a–6r. Reagents and conditions: (a) (CH2O)n, ZnCl2, 75 °C, 1 h; 110 °C, 12 h; (b) Dess–Martin periodinane, NaHCO3, 0 °C, 4 h; (c) thiosemicarbazide, H2O, EtOH, 65 °C, 15 min; (d) I2, K2CO3, 1,4-dioxane, 80 °C, 6 h; (e) RNCS, NaOH, 1,4-dioxane, 90 °C, 8–12 h.
