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. 2021 Mar 19;13(6):1414. doi: 10.3390/cancers13061414

Figure 3.

Figure 3

JAK-STAT signaling pathway and immune response evasion disturbances in ENKTCL. NKTCL biopsy carrying STAT3 activating mutation (c.1919A>T, p. Y640F) belonging to the tumor suppressors and immune modulators (TSIM) molecular group. Large-size tumor cells in a necrosis background are depicted (H&E) positive for pSTAT 3 and PD-L1. ENKTCL biopsy revealing STAT3 wild type. Neoplastic cells lacking an inflammatory background (H&E). In addition, P-STAT3 is negative in the tumor cells but positive in the vessels as an internal control, whereas PD-L1 is similarly negative in most of tumor cells but positive in some reactive histiocytes (H&E stain and Immunohistochemistry 400×). Abbreviations: H&E, hematoxylin and eosin; EBER, in situ hybridization for EBV-encoded small RNA.