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ENKTCL harboring MGA frameshift mutation (c.7586 G > A, p.H533*) associated with MYC overexpression belonging to the MB molecular group. ENKTCL with large cell morphology, cells are pleomorphic with pale cytoplasm, and irregular nuclei (H&E stain, 400×); all lymphoma cells show EBER positivity (in situ hybridization 200×) and MYC nuclear expression (immunohistochemistry 400×). Abbreviations: H&E, hematoxylin and eosin; EBER, in situ hybridization for EBV-encoded small RNA.
