Figure 6.

Combined effects of metformin and celecoxib. (A) OA was induced in Wistar rats by intra-articular injection of MIA. Metformin (50 mg/kg) and celecoxib (80 mg/kg) were orally administrated into OA rats for 14 days (N = 6 animals per group). Knee-joint tissue samples acquired from all OA groups at 14 days were stained with H&E and safranin O (B) to evaluate disease severity based on OARSI and Mankin scores. Data are represented as the mean ± SEM of three independent experiments (** p < 0.01, *** p < 0.001).