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. 2021 Mar 19;13(6):1396. doi: 10.3390/cancers13061396

Table 2.

VI-RADS scoring system [26].

Score Description
T2WI Score
Structural category (SC)
Muscularis propria is T2 hypointense
Tumor is T2 intermediate in signal
SC 1 Uninterrupted low signal intensity (SI) line representing the muscularis propria.
Lesion < 1 cm
Exophytic tumor
  • +/− stalk

  • +/− thickened inner layer (urothelium and lamina propria)

SC 2 Uninterrupted low signal intensity (SI) line representing the muscularis propria
Lesion > 1 cm
Exophytic tumor with stalk +/− high SI thickened inner layer, when present.
Sessile/broad-based tumor with high SI thickened inner layer, when present
SC 3 Lack of category 2 findings with no clear disruption of low SI muscularis propria. Associated presence of
  • Exophytic tumor without stalk

  • Sessile broad based tumor without high SI thickened inner layer.

SC 4 Intermediate SI tumor interrupts low SI line (muscularis propria)
SC 5 Intermediate SI tumor extends into extravesical fat
DCE Score
Contrast-enhanced category (CE)
Tumor and inner layer enhance early
Muscle should not enhance early
CE 1 No early enhancement of muscularis propria
CE 2 No early enhancement of muscularis propria with early enhancement of inner layer
CE 3 Lack of category 2 findings with no clear disruption of muscularis propria
CE 4 Early enhancing tumor extends into muscularis propria
CE 5 Early enhancing tumor extends to entire bladder wall and to extravesical fat
DWI/ADC score
Diffusion weighted category (DW)
Tumor is hyperintense on DWI, hypointense on ADC
Muscularis propria is intermediate SI on DWI
Stalk and inner layer are low SI on DWI
DW 1 Intact intermediate SI muscularis propria on DWI
Lesion < 1 cm
DW 2 Intact intermediate SI muscularis propria on DWI
Lesion > 1 cm
DW 3 Lack of category 2 findings with no clear disruption of muscularis propria
DW 4 Tumor (high SI on DWI/low SI on ADC) extends into muscularis propria
DW 5 Tumor (high SI on DWI/low SI on ADC) extends to entire bladder wall and extravesical fat
Final Score T2WI helpful especially for VI-RADS 1-3
DWI and DCE are dominant sequences for risk estimate, especially for VI-RADS 4-5
VI-RADS 1 Muscle invasion highly unlikely
SC 1, CE 1, and DW 1
VI-RADS 2 Muscle invasion unlikely
SC 2 + CE 2 and DW 2
SC 3 + CE 2 and DW 2
VI-RADS 3 Muscle invasion equivocal
SC 3 + CE 3 and/or DW 3 (or below)
VI-RADS 4 Muscle invasion likely
SC 4 + CE 4 and/or DW 4 (or below)
SC 5 + CE 4 and/or DW 4 (or below)
VI-RADS 5 SC 4 + CE 5 and/or DW 5
SC 5 + CE 5 and/or DW 5