Table 2.
Change in Echocardiographic Parameters after each Treatment.
| n= | After 1st Rx | After 2nd Rx | After 3rd Rx | |
|---|---|---|---|---|
| Δ EDV (µL) | ||||
| Vehicle | 18 | 4.0 ± 1.4 | 2.1± 0.6 | 2.1 ± 1.4 |
| Combined dose | 18 | −0.1 ± 1.5 | 1.7 ± 1.7 | −0.2 ± 1.6 |
| Multiple doses | 16 | −2.1 ± 1.7 # | 0.6 ± 2.2 | 3.5 ± 2.0 |
| Δ ESV (µL) | ||||
| Vehicle | 18 | 3.6 ± 1.0 | 1.8 ± 0.4 | 1.9 ± 1.0 |
| Combined dose | 18 | −3.3 ± 1.0 # | 0.6 ± 1.4 | −0.1 ± 1.3 |
| Multiple doses | 16 | −4.3 ± 1.3 # | −0.4 ± 1.8 | 0.5 ± 1.4 |
| Δ SV (µL) | ||||
| Vehicle | 18 | 0.5 ± 0.4 | 0.3 ± 0.2 | 0.1 ± 0.4 |
| Combined dose | 18 | 3.4 ± 0.6 # | 1.1 ± 0.7 | −0.1 ± 0.5 |
| Multiple doses | 16 | 2.4 ± 0.6 # | 0.8 ± 0.8 | 3.0 ± 0.9 †,§ |
| Δ EF (%) | ||||
| Vehicle | 18 | −0.8 ± 0.2 | −0.3 ± 0.1 | −0.5 ± 0.1 |
| Combined dose | 18 | 4.1 ± 0.5 # | 0.7 ± 0.8 | 0.1 ± 0.5 |
| Multiple doses | 16 | 3.7 ± 0.6 # | 0.8 ± 0.6 | 2.0 ± 0.5 †,§ |
Rx indicates treatment; EDV, end-diastolic volume; ESV, end-systolic volume; EF, ejection fraction. To distinguish from the group assignment, these four major parameters EDV, ESV, SV, and EF are bold and underlined. We present the absolute value of the changes after each treatment of these four major underlined parameters in this table. # p < 0.05 vs. Vehicle 1st Rx, † p < 0.05 vs. Vehicle 3rd Rx, § p < 0.05 vs. Combined dose 3rd Rx. All data are represented as the mean ± SEM.