Table 1.

Roles of m⁶A regulators in m⁶A RNA metabolism.

m6A Regulator	Roles in m6A RNA Metabolism	Reference
writers
METTL3-METTL14	reinitializes transcription during UV-induced DNA damage responses	[16]
WTAP	influences RNA alternative splicing	[17]
METTL16	promotes mRNA splicing	[18]
RBM15	mediates mRNA degradation	[19]
erasers
FTO	controls mRNA splicing	[20]
ALKBH5	impacts longer 3′-UTR mRNA splicing and stability	[21]
readers
YTHDC1	participates in transcriptional processes, mRNA splicing and mRNA nuclear export, promotes the exon inclusion of mRNA	[22,23,24]
YTHDC2	participates in mRNA translation and mRNA stability	[25,26]
YTHDF1	enhances translational efficiency of mRNA	[27]
YTHDF2	regulates mRNA degradation, circRNA degradation and miRNA degradation	[28,29,30]
YTHDF3	regulates mRNA translation, circRNA translation and mRNAs degradation	[31,32,33]
IGF2BPs	prevent mRNA degradation, promote mRNA stability and alter lncRNA gene expression	[34,35]
HNRNP particles	affects mRNA abundance, mRNA alternative splicing, mRNA gene expression, RNA maturation of mRNA and RNA export pathway	[36,37]
EIF3	regulates mRNA translation	[38]