Table 2.
Dual effects of m6A mRNA modification on non-small cell lung cancer (NSCLC).
| m6A Regulators | Role of m6A Modification in NSCLC | Function of m6A RNA in NSCLC | Reference |
|---|---|---|---|
| writers | |||
| METTL3 | oncogene | promotes cell EMT, migration and invasion | [70,71,72] |
| METTL14 | anti-oncogene | unclear | [73] |
| KIAA1429 | oncogene | promotes cell proliferation, invasion and migration | [74] |
| erasers | |||
| ALKBH5 | oncogene | promotes cell proliferation, invasion, migration and EMT | [75,76] |
| anti-oncogene | inhibits cell under IH proliferation and invasion | [77,78] | |
| FTO | anti-oncogene | inhibits cell proliferation and invasion | [79,80] |
| readers | |||
| YTHDF3 | oncogene | promotes cell growth, migration and invasion | [70] |
| YTHDF1 | oncogene | promotes cell growth, EMT and invasion | [75] |
| YTHDF2 | oncogene | promotes cell growth and proliferation | [81] |
| anti-oncogene | inhibits cell growth, EMT and invasion | [75] | |
| YTHDC2 | anti-oncogene | unclear | [82] |