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Kaplan–Meier estimates show that overall survival/disease-free survival is worse in patients with high EP4 expression. (a) Kaplan–Meier survival univariate analysis for the status cytoplasmatic IRS ≥ 3. Positive expression of EP4 in the cytoplasm significantly reduced overall survival (p = 0.001) (b) Kaplan–Meier survival univariate analysis for the status cytoplasmatic IRS ≥ 3. Positive expression of EP4 lead to decreased disease-free survival (p = 0.069).
