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The ubiquitination of substrates may vary in different constructions that play a role in various cell processes: protein interaction and localization (A), proteasomal degradation (B), NF-κB activation (C,D), DNA repair (C,E,F), lysosomal targeting (C), autophagy (E), intracellular trafficking (F) and epigenetic regulation (G), and many others still unknown functions (H). S—substrate, Ub—ubiquitin. Adapted from [5].
