Figure 3.

In vitro shear adhesion profile plotted as a function of distance for uncoated tablets. The oral gliding performance of tablets can be determined using a modified Hounsfield tensometer friction sledge across two non-anatomical oral mucosa-mimicking surfaces wetted with artificial saliva (polytetrafluoroethylene as graph (A) and sodium polyacrylate as graph (B)). Uncoated tablets displayed an erratic creep profile caused by a stick–slip motion resulting in friction re-strengthening and the fragmentation of the tablet, as depicted by the frequent large stress drops of the shearing peaks in both oral mucosa-mimicking surfaces.