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. 2021 Mar 20;22(6):3165. doi: 10.3390/ijms22063165

Figure 4.

Figure 4

Release of soluble FGFR is induced by the protein kinase C activator PMA and the calcium ionophore ionomycin. Shedding of FGFRs 1c (A), 2c (B), 3c (C), and 4 (D) from COS-7 cells incubated with phorbol 12-myristate 13-acetate (PMA, 25 ng/mL), ionomycin (IO, 2.5 μM), with or without the metalloprotease inhibitor DPC333 (DPC, 5μM). Shedding of FGFRs 1c, 3c, and 4 could be stimulated by PMA and IO, whereas shedding of FGFR2c was stimulated by IO but not by PMA. (*) indicates release of FGFR was significantly increased in cells treated with IO or PMA compared to untreated cells. n = 3, ±SEM; analysis via two-way ANOVA; * p ≤ 0.05.