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. 2021 Mar 19;11(3):792. doi: 10.3390/nano11030792

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) TEM micrograph of PLGA nanoparticles prepared by using 3 mg of sclareol (SCL); bar = 200 nm. (B) Mean sizes of PLGA nanoparticles prepared by using 3 mg of cholesterol (Chol) or sclareol (SCL) and then coated with hyaluronic acid (HA). (C) Entrapment efficiency of SCL as a function of the amount of active compound used during the preparation of PLGA nanoparticles. (D) Evaluation of the amount of HA adsorbed on the surface of PLGA nanoparticles prepared with 3 mg of SCL as a function of the amount of polysaccharide used. Reprinted with permission from [7]. Copyright ©2019 Elsevier Ltd.