Table 2.
Characterization of the B12 lipid vesicles in terms of size, polydispersity index (PDI), zeta-potential, drug loading, and phospholipid content (PC). All results are expressed as mean ± SD (n = 3).
| Formulations | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| L1 | L2 | L3 | T1c | T2c | T1d | T2d | E1 | E2 | |
| Size (nm) | 283 ± 6 | 278 ± 13 | 275 ± 9 | 175 ± 5 | 169 ± 10 | 177 ± 4 | 171 ± 3 | 150 ± 5 | 141 ± 11 |
| PDI | 0.269 ± 0.07 | 0.205 ± 0.002 | 0.215 ± 0.009 | 0.239 ± 0.02 | 0.261 ± 0.03 | 0.223 ± 0.01 | 0.244 ± 0.03 | 0.200 ± 0.003 | 0.193 ± 0.01 |
| Zeta potential (mV) | −11.2 ± 0.12 | −10.1 ± 0.3 | −9.55 ± 0.84 | −4.77 ± 0.13 | −5.01 ± 0.21 | −5.51 ± 0.17 | −5.17 ± 0.37 | −4.63 ± 0.75 | −5.35 ± 1.58 |
| Drug loading (mg per mL) | 1.9 ± 0.3 | 0.75 ± 0.07 | 0.17 ± 0.09 | 0.52 ± 0.02 | 0.14 ± 0.04 | 2.2 ± 0.2 | 0.60 ± 0.02 | 0.22 ± 0.03 | 0.23 ± 0.04 |
| PC (%) | 80 ± 4 | 84 ± 7 | 77 ± 2 | 33 ± 3 | 30 ± 0.9 | 86 ± 8 | 82 ± 5 | 66 ± 2 | 60 ± 5 |