Figure A1.

Nitrite (a marker for NO release) production by pulmonary artery over time. Rat pulmonary artery rings were treated with different combinations of 1 µg/mL LPS (to induce innate inflammation), 100 nM GW0742 (PPARβ/δ agonist), 1 µM GSK3787(PPARβ/δ antagonist), and the NO production was measured at 8 h, 20 h and 24 h of incubation (n = 3). The data are presented as mean ± standard deviation; the data was not normally distributed (D’Agostino–Pearson normality test). Significant difference by the Krustal-Wallis test with Dunns post hoc test is indicated by * = p < 0.05 compared with vehicle of same time point.