Table 1.
Baseline demographic and clinical data of 138-patient acute promyelocytic leukemia (APL) cohort differentiated by presence of FLT3-ITD and Sanz risk status.
| Variable | ITD (n = 59) |
WT (n = 79) |
p-Value | HR (n = 47) |
IR (n = 54) |
LR (n = 37) |
p-Value | ITD, HR (n = 37) |
WT, HR (n = 10) |
ITD, IR (n = 14) |
WT, IR (n = 40) |
ITD, LR (n = 8) |
WT, LR (n = 29) |
p-Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (Years) | 47 | 50 | 0.27 | 45 | 49 | 53 | 0.07 | 45 | 46 | 52 | 48 | 49 | 54 | 0.26 |
| Gender | M (44%) F (56%) |
M (52%) F (48%) |
0.39 | M (49%) F (51%) |
M (48%) F (52%) |
M (49%) F (51%) |
1.0 | M (49%) F (51%) |
M (50%) F (50%) |
M (43%) F (57%) |
M (50%) F (50%) |
M (25%) F (75%) |
M (55%) F (45%) |
0.80 |
| Ethnicity | W (53%) B (30%) O (17%) |
W (56%) B (20%) O (24%) |
0.33 | W (44% B (28%) O (28%) |
W (65%) B (22%) O (13%) |
W (52%) B (24%) O (24%) |
0.26 | W (46%) B (32%) O (22%) |
W (40%) B (10%) O (50%) |
W (72%) B (21%) O (7%) |
W (63%) B (22%) O (15%) |
W (50%) B (38%) O (12%) |
W (52%) B (21%) O (27%) |
0.39 |
| BMI | 32.3 | 31.8 | 0.74 | 31.7 | 32.2 | 31.9 | 0.97 | 32.3 | 29.9 | 33.6 | 31.7 | 30.1 | 32.4 | 0.91 |
| WBC | 29.9 | 5.1 | <0.001 | 41.8 | 2.8 | 1.5 | <0.001 | 45.9 | 26.7 | 4.2 | 2.3 | 1.5 | 1.6 | <0.001 |
| Hgb | 9.7 | 8.9 | 0.03 | 9.7 | 8.4 | 10.0 | <0.001 | 9.8 | 9.0 | 9.1 | 8.2 | 10.1 | 9.9 | 0.003 |
| Plt | 28.7 | 50.3 | 0.004 | 26.7 | 19.6 | 90.6 | <0.001 | 24.8 | 33.9 | 17.8 | 20.3 | 66.1 | 97.3 | <0.001 |
| Creat | 1.01 | 0.91 | 0.28 | 0.91 | 0.99 | 0.94 | 0.76 | 0.94 | 0.79 | 1.04 | 0.97 | 1.25 | 0.86 | 0.45 |
| AST | 44.5 | 30.2 | 0.001 | 49.3 | 27.6 | 32.4 | <0.001 | 49.8 | 47.6 | 28.4 | 27.4 | 48.6 | 27.9 | <0.001 |
| ALT | 44.8 | 33.7 | 0.09 | 50.1 | 29.2 | 36.9 | 0.02 | 51.2 | 46.1 | 30.5 | 28.8 | 40.3 | 36.0 | 0.16 |
| ALP | 83.7 | 81.4 | 0.73 | 86.8 | 68.8 | 95.9 | 0.002 | 87.8 | 83.1 | 68.1 | 69.0 | 90.0 | 97.6 | 0.02 |
| TBili | 1.0 | 0.9 | 0.42 | 1.1 | 0.9 | 0.8 | 0.05 | 1.0 | 1.2 | 1.0 | 0.8 | 0.6 | 0.8 | 0.11 |
| LDH | 968.1 | 1030.5 | 0.92 | 1145.4 | 1233.7 | 493.3 | 0.62 | 1172.9 | 1046.4 | 455.1 | 1506.3 | 944.5 | 368.9 | 0.86 |
| Fib | 168.2 | 225.0 | 0.003 | 160.4 | 183.4 | 277.3 | <0.001 | 153.8 | 184.9 | 159.9 | 191.6 | 249.3 | 285.0 | <0.001 |
| Morph | Classic (59%), Variant (41%) | Classic (94%), Variant (6%) | <0.001 | Classic (61%), Variant (39%) | Classic (85%), Variant (15%) | Classic (93%), Variant (7%) | 0.007 | Classic (52%), Variant (48%) | Classic (100%), Variant (0%) | Classic (67%), Variant (33%) | Classic (92%), Variant (8%) | Classic (80%), Variant (20%) | Classic (96%), Variant (4%) | 0.001 |
| BCR | 1 (26%), 2 (5%), 3 (53%), 1/2 (0%), 2/3 (16%) |
1 (62%), 2 (2%), 3 (22%), 1/2(12%), 2/3 (2%) |
<0.001 | 1 (29%), 2 (3%), 3 (52%), 1/2 (3%), 2/3 (13%) |
1 (59%), 2 (3%), 3 (22%), 1/2(10%), 2/3 (6%) |
1 (50%), 2 (5%), 3 (35%), 1/2 (5%), 2/3 (5%) |
0.22 | 1 (17%), 2 (4%), 3 (62%), 1/2 (0%), 2/3 (17%) |
1 (72%), 2 (0%), 3 (14%), 1/2(14%), 2/3 (0%) |
1 (33%), 2 (0%), 3 (45%), 1/2 (0%), 2/3 (22%) |
1 (70%), 2 (0%), 3 (13%), 1/2(13%), 2/3 (0%) |
1 (60%), 2 (20%), 3 (20%), 1/2 (0%), 2/3 (0%) |
1 (46%), 2 (0%), 3 (40%), 1/2 (7%), 2/3 (7%) |
0.002 |
| DS | Yes (46%), No (54%) | Yes (35%), No (65%) | 0.29 | Yes (49%), No (51%) | Yes (39%), No (61%) | Yes (30%), No (70%) | 0.20 | Yes (49%), No (51%) | Yes (50%), No (50%) | Yes (57%), No (43%) | Yes (32%), No (68%) | Yes (12%), No (88%) | Yes (34%), No (66%) | 0.22 |
| DIC | Yes (73%), No (27%) |
Yes (48%), No (52%) |
0.005 | Yes (79%), No (21%) | Yes (61%), No (39%) | Yes (30%), No (70%) | <0.001 | Yes (81%), No (19%) | Yes (70%), No (30%) | Yes (79%), No (21%) | Yes (55%), No (45%) | Yes (25%), No (75%) | Yes (31%), No (69%) | <0.001 |
| Bleeding | Yes (49%), No (51%) | Yes (41%), No (59%) | 0.39 | Yes (55%), No (45%) | Yes (48%), No (52%) | Yes (24%), No (76%) | 0.01 | Yes (57%), No (43%) | Yes (50%), No (50%) | Yes (43%), No (57%) | Yes (50%), No (50%) | Yes (25%), No (75%) | Yes (24%), No (76%) | 0.11 |
| ICH | Yes (14%), No (84%) | Yes (11%), No (89%) | 0.80 | Yes (19%), No (81%) | Yes (13%), No (87%) | Yes (3%), No (97%) | 0.06 | Yes (16%), No (84%) | Yes (30%), No (70%) | Yes (14%), No (86%) | Yes (12%), No (88%) | Yes (0%), No (100%) | Yes (3%), No (97%) | 0.23 |
| Clot | Yes (19%), No (81%) | Yes (11%), No (89%) | 0.33 | Yes (21%), No (79%) | Yes (7%), No (93%) | Yes (16%), No (84%) | 0.12 | Yes (22%), No (78%) | Yes (20%), No (80%) | Yes (14%), No (86%) | Yes (5%), No (95%) | Yes (12%), No (88%) | Yes (17%), No (83%) | 0.31 |
| CRinduc | Yes (89%), No (4%), Death (7%) |
Yes (93%), No (3%), Death (4%) |
0.70 | Yes (90%), No (5%), Death (5%) |
Yes (93%), No (0%), Death (7%) |
Yes (91%), No (6%), Death (3%) |
0.42 | Yes (88%), No (6%), Death (6%) | Yes (100%), No (0%), Death (0%) | Yes (85%), No (0%), Death (15%) | Yes (95%), No (0%), Death (5%) | Yes (100%), No (0%), Death (0%) | Yes (88%), No (8%), Death (4%) | 0.68 |
| CRcons | Yes (81%), No (4%), Death (15%) |
Yes (97%), No (0), Death (3%) |
0.02 | Yes (86%), No (6%), Death (8%) |
Yes (90%), No (0%), Death (10%) |
Yes (93%), No (0%), Death (7%) |
0.61 | Yes (83%), No (7%), Death (10%) | Yes (100%), No (0%), Death (0%) | Yes (75%), No (0%), Death (25%) | Yes (97%), No (0%), Death (3%) | Yes (86%), No (0%), Death (14%) | Yes (95%), No (0%), Death (5%) | 0.26 |
| 5-Year OS | 79.7% | 94.4% | 0.02 | 87.1% | 85.5% | 92.4% | 0.33 | 83.7% | 100% | 68.8% | 91.6% | 83.3% | 96.6% | 0.13 |
ITD = FLT3 internal tandem duplication mutation, WT = FLT3 wild-type, HR = Sanz high risk, IR = Sanz intermediate risk, LR = Sanz low risk, Age = mean age in years, Gender = male (M) or female (F), Ethnicity (white = W, black = B, other = O), BMI = admission body mass index, WBC = admission white blood cell count in ×109/L, Hgb = admission hemoglobin in g/dL, Plt = admission platelet count in ×109/L, Creat = admission creatinine in mg/dL, AST = admission aspartate aminotransferase in units/L, ALT = admission alanine aminotransferase in units/L, ALP = admission alkaline phosphatase in units/L, TBili = admission total bilirubin in mg/dL, LDH = admission lactate dehydrogenase in units/L, Fib = admission fibrinogen in mg/dL, Morph = classic or variant, BCR = breakpoint cluster region, DS = differentiation syndrome during induction, DIC = disseminated intravascular coagulation during induction, Bleeding = any bleeding event during induction, ICH = intracranial hemorrhage during induction, Clot = any thrombotic event during induction, CRinduc. = complete remission after induction, CRcons. = complete remission after consolidation, OS = overall survival (survivor function %) in 5 years.