Figure 2.

Endoglin acting in communication within the tumor microenvironment. Membrane-bound endoglin expression by several cell types within the tumor microenvironment (e.g., CAFs, macrophages, immune, and endothelial cells) and how its secretion (either soluble and/or in EVs) contributes to tumor progression and metastasis in different cancer models, making it a promising target for therapeutic strategies. Transforming growth factor β (TGFβ), bone morphogenic protein (BMP), matrix metalloproteinase 14 (MMP14), regulatory T cells (Tregs), extracellular vesicle (EV).