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. 2021 Mar 20;22(6):3188. doi: 10.3390/ijms22063188

Figure 2.

Figure 2

The effect of M.C treatment on body weight loss and dietary intake measurements in mice with cisplatin-induced sarcopenia. To induce muscle damage, cisplatin (2.5 mg/kg) was administered on days 1–5 and 26–30. Magnolol (10 mg/kg) was administered intraperitoneally every 3 days, for a total of 12 times. M.C (50, 100, and 200 mg/kg) was administered orally every 3 days, for a total of 12 times. Mice were sacrificed on day 42: (A) weight changes in the sarcopenia mouse model. Data are presented as the mean ± SEM (n = 10/group). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. cisplatin, using a Bonferroni post hoc test after two-way ANOVA; (B) weight changes in the sarcopenia mouse model presented as % vs. control (42 days); (C) representative colon images (scale bar 1 cm) and colon length measurement; (D) average daily feed intake per mouse. Data are presented as the mean ± SEM (n = 10/group). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. cisplatin (CIS)+phosphate-buffered saline (PBS), using a Bonferroni post hoc test after one-way ANOVA.