Table 1.
Serum levels of total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), aspartate transaminase (AST), and alanine transaminase (ALT) after 8 weeks of treatment. Mean and standard error (n = 6) of the following Goto-Kakizaki (GK) rat groups: control group (Control), high-fat diet group (HFD), ezetimibe/atorvastatin raw material (EZ/ATV-RM), multiparticulate systems MPS-I and MPS-II.
| Control | HFD | EZ/ATV-RM | MPS-I | MPS-II | |
|---|---|---|---|---|---|
| TC (mmol/L) | 117.80 ± 8.17 | 181.00 ± 21.56 | 142.43 ± 10.20 ӿ | 106.00 ± 11.15 ӿ # | 106.29 ± 8.24 ӿ # |
| TG (mmol/L) | 98.25 ± 16.88 | 169.67 ± 11.38 | 134.00 ± 15.71 ӿ | 85.80 ± 18.58 ӿ # | 87.33 ± 10.07 ӿ # |
| LDL (mmol/L) | 48.55 ± 5.14 | 119.27 ± 7.94 | 80.23 ± 7.22 ӿ | 46.44 ± 6.13 ӿ # | 44.82 ± 5.85 ӿ # |
| HDL (mmol/L) | 49.60 ± 4.27 | 27.80 ± 4.97 | 35.40 ± 3.21 | 42.40 ± 5.13 ӿ | 44.00 ± 4.06 ӿ # |
| ALT (U/L) | 74.40 ± 8.02 | 80.40 ± 9.13 | 69.83 ± 7.86 | 64.00 ± 7.35 ӿ | 63.40 ± 7.96 ӿ |
| AST (U/L) | 180.00 ± 11.05 | 205.17 ± 25.42 | 153.50 ± 19.82 ӿ | 142.25 ± 14.80 ӿ | 126.80 ± 17.57 ӿ |
(ӿ) significant difference (p < 0.05) compared with HFD group; (#) significant difference (p < 0.05) of MPS-I and MPS-II groups compared with EZ/ATV-RM group.