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. 2021 Mar 21;13(6):1433. doi: 10.3390/cancers13061433

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression of mRNA corresponding to the two main isoforms of ZNF518B to show that the isoform ratio correlates with the relapse of patients. (A) Differences in isoform level in tumour samples (a cohort of 66 patients was analysed). (B–H) Violin plots showing the changes in the ratio between isoform 2 and isoform 1 mRNA with respect to the clinicopathological properties of the patients’ cohort. In panels B and C, T and N stages are indicated in the conventional way. (I) Disease-free survival of patients as a function of the isoform 2/isoform 1 ratio. Patients were categorised in high- or low-ratio groups according to the median value of the ratio in the cohort. (J) Correlation of the ratio between isoform 2 and isoform 1 with the consensus molecular subtypes (CMS) classification. *, p < 0.05; ***, p < 0.001.