Table 1.
Gene ontology of the alterations induced in the transcriptome of DLD1 and HCT116 cells by silencing the ZNF518B gene.
| Biological Pathway | Up-Regulated Genes (n) | Down-Regulated Genes (n) |
|---|---|---|
| EGFR pathway | 14 | 14 |
| Signalling VEGFR2 | 16 | 27 |
| PI3K-AKT pathway | 26 | 17 |
| MAPK pathway | 21 | 18 |
| WNT pathway | 8 | 9 |
| TGF-β signalling pathway | 13 | 13 |
| RAS pathway | 16 | 8 |
| Biological processes | Up-regulated genes (n) | Down-regulated genes (n) |
| Cell cycle | 9 | 20 |
| EMT in CRC | 12 | 9 |
| Apoptosis | 8 | 12 |
| Histone modification | 4 | 13 |
| Focal adhesion | 20 | 9 |
| Focal adhesion via PI3K-AKT-mTOR | 25 | 13 |
| Only the genes related to cancer-linked processes are included. | ||