Figure 1. Modeling approach and promoter configuration occurrences.

(A) Simplified nucleosome dynamics at the PHO5 promoter including assembly, disassembly and sliding from a site-centric point of view. Dashed circles indicate possible nucleosome positions. Pho4-binding sites (UASp elements) are represented by small circles. (B) Configuration-specific modeling approach with eight promoter configurations and 32 reactions. Arrow color code as in panel A. (C) Measured relative occurrences of the eight promoter configurations indicated at the bottom as in panel B but rotated by 90° and for three different ‘promoter states’: the repressed wild-type, a weakly activated mutant (pho4[85-99] pho80$\mathrm{\Delta }$tata) and the activated mutant (pho80$\mathrm{\Delta }$), using data from Brown et al., 2013.