Table 1.
Summary of the different combinations of the mutations in the “host” and “guest” cells and their effect on the lipid hydroperoxide profile and cell death.
| GUEST/HOST | A549 wt |
A549 ASCT1KO |
A549 ASCT2KO |
A549 ASCT1-ASCT2DKO |
A549 LAT1KO |
|---|---|---|---|---|---|
| MiaPaCa-2 wt |
= ✓ | = ✓ | = ✓ | = ✓ | = ✓ |
| MiaPaCa-2 xCTKO |
= ✓ | = ✓ | ↑ ✓ | ↑ ✗ | = ✓ |
| MiaPaCa-2 xCT-ASCT2DKO |
= ✓ | = ✓ | ↑ ✗ | ↑ ✗ | = ✓ |
* =, no change in the lipid hydroperoxide profile; ↑, increase in the lipid hydroperoxide content; ✓, no cell death; ✗, cell death observed.