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. 2021 Mar 22;19(3):171. doi: 10.3390/md19030171

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression and interaction assays of proteins that were significantly downregulated by the treatment of EPS364 for 5 h, as shown in the proteomic results. (A) The relative mRNA levels of different genes related to cancer cell growth, adhesion and the FGF19-FGFR4 signaling pathway were detected by qRT-PCR after different concentrations of the EPS364 (0–1.2 mg/mL) treatment. (B) The interactions of the cancer cell growth, adhesion and FGF19-FGFR4 signaling pathway-related proteins were analyzed by String software. Data are presented as means ± SD of three independent experiments (n = 3). * p < 0.05 and ** p < 0.01 versus the EPS364-treated group. Abbreviations: FGFR4, fibroblast growth factor receptor 4; KLB, β-klotho; CTNNB1, β-catenin; ALCAM, activated leukocyte cell adhesion molecule; ICAM1, intercellular adhesion molecule 1; AFP, α-fetoprotein; CAV1, caveolin-1; CAV2, caveolin-2; CDH2, N-cadherin and FGF19, fibroblast growth factor 19.