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Proposed antitumor model of EPS364. EPS364 downregulated the FGF19-FGFR4 signaling axis, which induced the collapse of the MMP and generation of ROS. FGF19-FGFR4 signaling downregulated the downstream molecules, such as CTNNB1, ICAM1, CDH2 and ALCAM. Consequently, EPS364 induced apoptosis and inhibited cell growth and adhesion.
