Table 3.
List of approved drugs using HYALs. This table comprises a collection of drugs leveraging HYALs as either a primary or secondary component for the treatment of various conditions and diseases. All drugs are administered via subcutaneous injection, which benefits from HYALs degrading HA in the skin for increased absorption of the active ingredient. All listed drugs are approved by the FDA.
| Brand Name | Composition | Mechanism | Use | Species Origin |
|---|---|---|---|---|
| Amphadase | HYAL | Dispersion agent to hydrolyze HA | Adjuvant for hydration | Bovine testicular |
| Darzalex Faspro | Daratumumab, HYAL | HYAL depolymerizes HA to increase absorption of daratumumab | Multiple myeloma | Recombinant human |
| Herceptin Hylecta | Trastuzumab, HYAL | HYAL depolymerizes HA to increase absorption of trastuzumab | Adjuvant for breast cancer | Recombinant human |
| Hylenex | HYAL | Dispersion agent to hydrolyze HA | Adjuvant for hydration | Recombinant human |
| Hyqvia | IgG, HYAL | HYAL depolymerizes HA to increase absorption of immunoglobulin G | Replacement therapy for immunodeficiency | Recombinant human |
| Rituxan Hycela | Rituximab, HYAL | HYAL depolymerizes HA to increase absorption of rituximab | Various lymphomas | Recombinant human |
| Vitrase | HYAL | Dispersion agent to hydrolyze HA | Adjuvant for hydration | Ovine testicular |