Table 1.
Effects of curcumin on inflammation in obesity: human studies.
| Study Design | Subjects | Treatment | Duration | Outcomes | References |
|---|---|---|---|---|---|
| Randomized double-blind, placebo-controlled |
Overweight/obese with NAFLD (males and females, n = 84) |
42 curcumin (40 mg/day) 42 placebo |
3 months | ↓TNF-alpha and IL-6 | [53] |
| Randomized, double-blind, placebo-controlled |
Overweight/obese with MetS (males and females, n = 117) |
59 curcumin (1 g/day) 58 placebo |
8 weeks | ↓TNF-α, IL-6, and MCP-1 | [7] |
| Randomized, double-blind, placebo-controlled |
Overweight/obese (adolescent girls, n = 60) | 30 curcumin (500 mg/day) 30 placebo |
10 weeks | ↓IL-6 | [54] |
| Randomized, double blind, crossover |
Obese (males and females, n = 30) |
15 curcumin (1g/day + 5 mg bioperine) 15 placebo |
4 weeks each treatment + 2 weeks wash-out between the regimens. |
↓IL-1β no changes IL-6, and MCP-1 |
[55] |
| Randomized, double-blind, placebo-controlled |
Overweight/obese with T2D (males and females, n = 100) |
50 curcumin (300 mg/day) 50 placebo |
3 months | ↓FFA | [56] |
| Randomized, double-blind, placebo-controlled |
T2D (unspecified gender n= 100) |
50 curcumin (1 g + 10 mg piperine/day) 50 placebo |
12 weeks | ↓TNF-α and Leptin ↑ Adiponectin |
[64] |
| Randomized, double-blind, placebo-controlled |
Overweight with T2D (males and females, n = 44) | 21 curcumin (1500 mg/day) 23 placebo |
10 weeks | ↑ Adiponectin ↓weight |
[66] |
| Randomized, double-blind, placebo-controlled |
Obese (males and females, 29 adults, 29 children) |
15 children curcumin (500 mg/day) 14 children placebo 15 adults curcumin (500 mg/day) 14 adults placebo |
4 weeks | ↓Leptin ↓Resistin ↑Adiponectin |
[68,69] |
| Randomized, double-blind, placebo-controlled |
Obese with MetS (males and females, n = 120) |
40 curcumin (1 g/day) 40 placebo 40 phospholipidated curcumin (1 g/day) |
6 weeks | ↑ Adiponectin | [65] |
| Randomized, double-blind, placebo-controlled |
Overweight T2D (males and females, n = 210) |
107 curcumin (1.5 g/day) 103 placebo |
6 months | ↓ Leptin ↑ Adiponectin |
[70] |
| Randomized double-blind, placebo-controlled |
Overweight\obese with NAFLD (males and females, n = 46) |
23 curcumin (3 g/day) 23 placebo |
12 weeks | ↓Leptin | [71] |
| Randomized double-blind, placebo-controlled |
Obese (males, n = 22) |
11 curcumin (500 mg/day) 11 placebo |
12 weeks | no change Adiponectin | [67] |
Abbreviations: ↑ Increases; ↓ Decreases; IL-6, interleukin-6; IL-1β, interleukin-1β; MCP-1, monocyte chemoattractant protein-1; TNFα, tumor necrosis factor α; FFA, free fatty acids; T2D, type 2 diabetes; MetS, metabolic syndrome; NAFLD; nonalcoholic fatty liver disease.