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The schematic organization of NS5A domains. (a) NS5A contains an N-terminal amphipathic α-helix critical for its targeting of the membrane and three domains (domains I, II and III) separated by two low-complexity sequences (LCS). (b) NS5A inhibitors bind the dimerized domain I, thereby potentially blocking NS5A to exert its functions (PDB: 3FQQ). RAVs of NS5A inhibitors are often in M28, Q30, L31, and Y93.
