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. 2021 Mar 22;22(6):3216. doi: 10.3390/ijms22063216

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regional association plots showing the jointly significant TWAS genes. (A) A regional association plot at chromosome 17 from blood tissue of YFS. (B) A regional association plot at chromosome 11 from the brain cortex of GTEx. Color bars on the top panel show all of the protein-coding genes and/or TWAS genes. Jointly significant genes are highlighted using green bars while marginally significant genes are highlighted using blue bars. A scatter plot at the bottom shows a Manhattan plot of the GWAS data before (gray) and after (blue) conditioning on the independently significant genes.