Table 1.
Significant TWAS novel risk genes for ALS (FDR < 0.05). GTEx, Genotype-Tissue Expression project v7; YFS, Young Finns Study; NTR, Netherlands Twin Registry.
| Gene | Tissue Panel | Chr | Best GWAS rsID | TWAS Z-Score | TWAS p-Value | FDR |
|---|---|---|---|---|---|---|
| RSPH10B | GTEx—Pituitary | 7 | rs709930 | −4.68 | 2.90 × 10−6 | 6.43 × 10−3 |
| NDUFC2 | GTEx—Brain Cortex | 11 | rs665278 | −4.25 | 2.18 × 10−5 | 3.04 × 10−2 |
| HDGFRP3 | YFS—Blood | 15 | rs13329195 | −4.26 | 2.39 × 10−5 | 3.24 × 10−2 |
| USP37 | NTR—Blood | 2 | rs933994 | 4.20 | 2.74 × 10−5 | 3.54 × 10−2 |
| NDST2 | YFS—Blood | 10 | rs12256103 | 4.13 | 3.57 × 10−5 | 4.22 × 10−2 |
| LCE1C | GTEx—Brain Cerebellar Hemisphere | 1 | rs3126091 | −4.11 | 3.93 × 10−5 | 4.50 × 10−2 |
| TRBC2 | NTR—Blood | 7 | rs1964986 | −4.09 | 4.28 × 10−5 | 4.83 × 10−2 |