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. 2021 Mar 10;2021:8818356. doi: 10.1155/2021/8818356

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Copyright © 2021 A. S. Devika et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The publication of this article was funded by Max Planck Society, DST/SERB, DBT, ICMR and KSCSTE.

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Human ESC/EpiSC culture condition leads naïve ESCs to distinct EpiSC-like states. (a) Brightfield images of the indicated samples (scale bars 100 μm). mESCs were brought to naïve state with LIF/2i (LIF+2i (PD0325901+CHIR99021)), followed by AA/F2 treatment. This treatment results in morphological changes from round dome-shaped to flat colonies. (b) Principal component analysis (PCA) of the indicated samples. (c) Heat map, based on Pearson's correlation coefficient. AA/F2 treatment for different durations led naïve ESCs to primed EpiSC states that differed from each other and the PSCs that were compared here.