Table 2.
Parameter variations according to meta − analysis results (values are expressed as mean change and 95% CI)
| Parameter | Drug | |||||
|---|---|---|---|---|---|---|
| Aripiprazole | Lurasidone | Olanzapine | Paliperidone XR | Quetiapine XR | Risperidone | |
| Δ Weight (kg) | 2.73* (0.53, 4.94) | 0.43 (− 0.93, 1.79) | 4.52* (3.62, 5.42) | 0.88 (− 0.75, 2.51) | 1.83* (0.37, 3.29) | 4.19* (3.30, 5.07) |
|
Δ BMI (kg/m2) |
1.48 (− 0.04, 3.00) | − 0.10 (− 0.35, 0.16) | 1.59* (0.97, 2.21) | 0.59 (− 0.34, 1.53) | 0.74 (− 0.36, 1.85) | 0.61* (0.53, 0.69) |
| Δ Total cholesterol (mg/dL) | 11.67 (− 0.01, 23.35) | − 8.01 (− 9.45, − 6.57) | 13.07* (9.60, 16.53) | 14.69 (− 1.54, 30.92) | 10.55 (− 0.33, 21.43) | 4.40 (− 4.46, 13.26) |
|
Δ Cholesterol HDL (mg/dL) |
− 0.62 (− 2.15, 0.90) | − 2.05 (− 2.47, − 1.63) | − 1.25 (− 2.73, 0.23) | 0.57 (− 1.05, 2.19) | − 1.74* (− 2.92, − 0.56) | − 1.08 (− 2.84, 0.67) |
|
Δ Triglycerides (mg/dL) |
18.63* (1.67, 35.58) | − 5.33* (− 6.55, − 4.10) | 33.10* (21.93, 44.27) | 7.15 (− 14.96, 29.25) | 14.25* (2.92, 25.59) | 9.39 (− 7.77, 26.54) |
|
Δ Fasting glucose (mg/dL) |
0.19 (− 4.22, 4.59) | 1.78 (− 18.39, 21.96) | 6.24* (4.38, 8.10) | 3.20* (0.10, 6.29) | − 0.59 (− 5.37, 4.18) | 2.97* (0.30, 5.64) |
| Δ Systolic blood pressure (mm Hg) | 0.84 (− 3.25, 4.93) | − 0.61 (− 1.32, 0.10) | 1.64 (− 1.43, 4.72) | 1.29 (− 1.48, 4.06) | 2.60* (0.04, 5.16) | 1.07 (− 1.12, 3.26) |
| Δ Diastolic blood pressure (mm Hg) | 1.00 (− 3.01, 5.01) | 0.13 (− 0.24, 0.50) | 0.55 (− 1.08, 2.18) | − | 2.77* (0.35, 5.19) | 1.35 (− 1.48, 4.18) |
*Statistical significance
BMI body mass index, CI, confidence interval, HDL high-density lipoprotein, XR extended release