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. 2020 Nov 25;78(6):3005–3020. doi: 10.1007/s00018-020-03703-8

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© The Author(s) 2020

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Fig. 3 — Effect of 3D culturing on the miRNA cargo of PDAC cell-derived EVs is dependent on the matrix. a–b The morphology of the colonies in different matrices (left panels) and correlations between the miRNA levels of EV samples from 2D and 3D cultures in the indicated matrices for Panc08.13 (a) and Panc10.05 (b) cells (low-density miRNA cards). Ct values were normalized to the level of miR-19b. c The number and percentage of the overlapping and non-overlapping miRNAs of Panc08.13 (blue color) and Panc10.05 (yellow circles) cell-derived EVs cultured under the indicated conditions. Scale bars: 50 µm (a, b)