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. 2021 Mar 16;8:641734. doi: 10.3389/fmolb.2021.641734

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Copyright © 2021 Villar-Fincheira, Sanhueza-Olivares, Norambuena-Soto, Cancino-Arenas, Hernandez-Vargas, Troncoso, Gabrielli and Chiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-6 signaling in vascular remodeling induced by exercise. High intensity and long duration exercises induce a large plasma level increase of interleukin-6 (IL-6), and a modest increase in soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130). However, basal levels of sIL-6R and spg130 are at least hundred times higher than those of IL-6. IL-6 activates classical signaling, whereas the complex IL-6/sIL-6R activates trans-signaling. Trans-signaling is specifically regulated by sgp130. The role of IL-6 signaling and trans-signaling in vascular remodeling induced by exercise is unknown.