Table 3.

Significant correlation of lower MMSE scores with altered activation in specific brain regions

Contrast	Task	r	R/L	MNI coordinates			Macroanatomical and cytoarchitectonic region
				x	y	z
Controls > MCI	Retrieval verbal	−0.8	R	32	28	−2	Anterior insula lobe, inferior frontal gyrus
(MCI + AD) > Controls	Encoding	−0.51	R	10	−58	36	Precuneus
(MCI + AD) > Controls	Encoding images	−0.61	R	10	−58	36	Precuneus
Controls > (MCI + AD)	Retrieval images	−0.85	R	26	−18	−20	PHG, hippocampus (maximum: SUB)
							Distribution: 42 % in SUB, 40 % in CA, 10 % in EC, 7 % in amygdala (LB)
							CA manually: CA1, CA3, CA4

r Spearman correlation coefficient, R right, L left, MNI Montreal Neurological Institute, MCI mild cognitive impairment, AD Alzheimer’s disease, PHG parahippocampal gyrus, EC entorhinal cortex, SUB subiculum, CA = cornu ammonis, LB laterobasal