Table 3.
Logistic regression of determinants of the severity of NAFLD.
| Moderate to Severe NAFLD | Crude OR (95% Cl) | p-Value | Adjusted OR (95% Cl) | p-Value |
|---|---|---|---|---|
| Clinical data | ||||
| Age, year | 0.97 (0.93–0.99) | 0.03 | 0.99 (0.95–1.03) | 0.73 |
| Sex (female vs. male) | 1.68 (0.89–3.20) | 0.11 | 2.57 (1.17–5.67) | 0.02 |
| Body mass index, kg/m2 | 1.34 (1.19–1.50) | <0.001 | 1.28 (1.12–1.46) | <0.001 |
| Smoke (yes vs. no) | 1.37 (0.69–2.72) | 0.37 | - | - |
| Alcohol (yes v.s. no) | 1.27 (0.60–2.67) | 0.53 | - | - |
| Diet habit, % | ||||
| Fiber more than protein | 0.42 (0.15–1.20) | 0.11 | ||
| Laboratory data | ||||
| Creatinine, mg/dL | 0.84 (0.45–1.56) | 0.59 | - | - |
| Hemoglobin, g/dL | 1.13 (0.93–1.36) | 0.22 | - | - |
| Albumin, g/dL | 2.05 (0.82–5.11) | 0.13 | - | - |
| Uric acid, mg/dL | 1.06 (0.86–1.29) | 0.59 | - | - |
| GOT | 1.02 (0.99–1.05) | 0.17 | - | - |
| GPT | 1.04 (1.01–1.06) | 0.004 | 1.01 (0.98–1.03) | 0.49 |
| Cholesterol, mg/dL | 1.00 (0.99–1.01) | 0.68 | − | − |
| Log (Triglyceride) | 12.12 (3.14–46.82) | <0.001 | 5.18 (0.91–29.65) | 0.07 |
| HDL, mg/dL | 0.97 (0.94–0.99) | 0.02 | 0.99 (0.95–1.02) | 0.53 |
| LDL, mg/dL | 1.01 (0.99–1.01) | 0.44 | - | - |
| HbA1c, % | 1.26 (0.98–1.60) | 0.07 | - | - |
| Log (urine ACR) | 0.97 (0.66–1.41) | 0.86 | - | - |
| Log (C-reactive protein) | 0.68 (0.31–1.47) | 0.32 | - | − |
| Microbiome | ||||
| Log(Firmicutes/g) | 2.71 (1.13–6.48) | 0.02 | 3.68 (1.30–10.46) | 0.01 |
| Log (Bacteroidetes/g) | 1.52 (0.86–2.67) | 0.14 | - | - |
| Log (Firmicutes/Bacteriodetes) | 1.02 (0.51–2.04) | 0.95 | - | - |
| Log (C. leptum group/g) | 1.56 (0.86–2.85) | 0.14 | - | - |
| Log (Bacteroides/g) | 1.39 (0.80–2.42) | 0.24 | - | - |
| Log (Bifidobacterium/g) | 1.14 (0.92–1.41) | 0.23 | - | - |
| Log (F. prausnitzii/g) | 0.97 (0.72–1.31) | 0.84 | - | - |
| Log (A. muciniphila/g) | 0.94 (0.80–1.08) | 0.37 | - | - |
| Log (E.coli/g) | 0.93 (0.69–1.24) | 0.60 | - | - |
Abbreviations: OR, odds ratio; DPP4, dipeptidyl peptidase 4; GOT, Glutamate oxaloacetate transaminase; GPT, Glutamate pyruvate transaminase.