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. 2021 Mar 22;10(3):247. doi: 10.3390/biology10030247

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of promoter methylation status in HSP members differentially expressed in BC. For each HSP member the levels of promoter methylation between normal and breast cancer were retrieved from UALCAN database. Beta value cut-off indicates hyper-methylation [beta value: 0.7–0.5] or hypo-methylation [beta-value: 0.3–0.25]. HSP members with hyper-methylated promoters are marked in green; HSP members with hypo-methylated promoters are marked in black. Box plots showing the promoter methylation status between normal and breast primary tumors in HSPs up-regulated (A) and down-regulated in BC (B). p < 0.01 was considered significant.