Table 3.
List of HSP members significantly associated with clinical outcome, including Relapse Free Survival (RFS), Overall Survival (OS), and Distant Metastasis Free Survival (DMFS), evaluated by KM Plotter database. The Log Rank value was marked in red when higher expression of selected HSP was associated with poor prognosis and in the black when higher expression of selected HSP was associated with a good prognosis. The probe expression value cut-off for each analysis is also reported.
| Gene | RFS | OS | DMFS | |||
|---|---|---|---|---|---|---|
| Used Cut-Off | Logrank P | Used Cut-Off | Logrank P | Used Cut-Off | Logrank P | |
| HSP90AA1 | 20,364 | <1 × 10−16 | 23,504 | 5.7 × 10−7 | 20,054 | 3.8 × 10−4 |
| HSPA1A | 9077 | 9.4 × 10−5 | 13,346 | 2.5 × 10−3 | 9089 | 8 × 10−4 |
| HSPA1B | 2046 | 8.3 × 10−4 | 1254 | 9.2 × 10−4 | 1829 | 6.8 × 10−3 |
| HSPA8 | 14,679 | <1 × 10−16 | 14,679 | 5.5 × 10−3 | 14,018 | 1.7 × 10−2 |
| HSPA14 | 490 | 1.7 × 10−5 | 477 | 1.7 × 10−4 | 490 | 2.2 × 10−3 |
| TCP1 | 601 | 7.4 × 10−11 | 676 | 1.5 × 10−7 | 562 | 1.2 × 10−4 |
| CCT2 | 5366 | <1 × 10−16 | 5370 | 2.7 × 10−8 | 4520 | 2 × 10−7 |
| CCT3 | 4554 | 2.9 × 10−15 | 4619 | 1.2 × 10−2 | 4735 | 1.9 × 10−3 |
| CCT4 | 5934 | 1.10 × 10−11 | 5587 | 2.9 × 10−2 | 6778 | 3.32 × 10−2 |
| CCT6A | 1676 | <1 × 10−16 | 1667 | 2 × 10−8 | 1678 | 7.6 × 10−6 |
| CCT7 | 2498 | <1 × 10−16 | 2394 | 5 × 10−4 | 2466 | 1.4 × 10−3 |
| CCT8 | 5676 | <1 × 10−16 | 4599 | 5.5 × 10−5 | 3613 | 1.1 × 10−4 |
| HSPD1 | 11,874 | <1 × 10−16 | 11,640 | 7.7 × 10−7 | 10,253 | 5.6 × 10−6 |
| DNAJA1 | 5070 | 2 × 10−14 | 4099 | 2.7 × 10−4 | 4939 | 1 × 10−4 |
| DNAJB1 | 2284 | 8.7 × 10−4 | 2312 | 4 × 10−2 | 2369 | 1.1 × 10−2 |
| DNAJB11 | 1771 | 1.3 × 10−9 | 2300 | 4.20 × 10−2 | 1910 | 2.5 × 10−4 |
| DNAJC2 | 1153 | 2.5 × 10−16 | 781 | 1.7 × 10−3 | 1049 | 9.1 × 10−4 |
| DNAJC5 | 768 | 3.9 × 10−2 | 748 | 1.8 × 10−3 | 591 | 4.8 × 10−2 |
| DNAJC9 | 1494 | <1 × 10−16 | 1296 | 1.5 × 10−7 | 1328 | 1.3 × 10−6 |
| DNAJC17 | 128 | 1.6 × 10−2 | 128 | 2 × 10−2 | 163 | 3.6 × 10−3 |
| HSPB1 | 9981 | 2.4 × 10−12 | 5940 | 3.5 × 10−4 | 7584 | 1.3 × 10−7 |
| HSPA2 | 536 | 2.2 × 10−10 | 624 | 5.8 × 10−5 | 563 | 1.7 × 10−6 |
| BBS12 | 186 | 1 × 10−10 | 185 | 3.8 × 10−4 | 187 | 4.7 × 10−3 |
| DNAJB8 | 26 | 4 × 10−5 | 23 | 3.7 × 10−2 | 24 | 7.4 × 10−3 |
| DNAJB12 | 644 | 6.4 × 10−10 | 644 | 1.5 × 10−2 | 879 | 2.5 × 10−2 |
| DNAJB14 | 757 | 5.5 × 10−8 | 1147 | 1.2 × 10−4 | 1164 | 2.7 × 10−2 |
| DNAJC4 | 487 | 3.3 × 10−10 | 489 | 9 × 10−3 | 445 | 2.9 × 10−3 |
| DNAJC5G | 54 | 1.3 × 10−8 | 27 | 2.3 × 10−3 | 54 | 1.5 × 10−2 |
| DNAJC10 | 171 | 5.3 × 10−12 | 202 | 9.6 × 10−3 | 187 | 4.3 × 10−2 |
| DNAJC12 | 92 | 1.4 × 10−7 | 127 | 5.3 × 10−4 | 92 | 1.8 × 10−5 |
| DNAJC14 | 433 | 3.8 × 10−10 | 393 | 5.2 × 10−3 | 529 | 1.5 × 10−2 |
| DNAJC16 | 402 | 8.3 × 10−11 | 361 | 5.8 × 10−9 | 402 | 4.7 × 10−8 |
| DNAJC19 | 562 | 1.4 × 10−10 | 578 | 1.6 × 10−7 | 578 | 3.1 × 10−7 |
| CRYAB | 575 | 1.7 × 10−2 | 522 | 3.8 × 10−3 | 848 | 3.2 × 10−2 |