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The effect of caMRAP2 on signaling properties of caMC4R.
| caMC4R/caMRAP2 | α-MSH | ACTH (1–24) | ||
|---|---|---|---|---|
| EC50 (nM) | Rmax (%) | EC50 (nM) | Rmax (%) | |
| 1:0 | 0.48 ± 0.12 | 100 | 0.45 ± 0.20 | 100 |
| 1:5 | 0.61 ± 0.15 | 44.70 ± 7.96 c | 0.42 ± 0.13 | 54.81 ± 5.19 c |
Results are expressed as the mean ± SEM of at least three independent experiments. c Significantly different from the parameter of 1:0, p < 0.001.
