Table 5.
Screening of commercially available compounds with structures inspired by ascididemin.
| Name and CAS no. | Structures | MRSA | E. coli | P. aeruginosa | M. tuberculosis | HepG2 | HEK 293 | A549 | THP-1 |
|---|---|---|---|---|---|---|---|---|---|
| Isoquinoline 119-65-3 |
|
>100 | >100 | >100 | 0.1 | 3 | >100 | 50 | 3 |
| Quinoline 91-22-5 |
|
>100 | >100 | >100 | 0.1 | 3 | 50 | 50 | 3 |
| 4,7-phenanthroline 230-07-9 |
|
1.5 | 1.5 | 2.5 | 2.5 | >100 | >100 | >100 | >100 |
| 1,7-phenanthroline 230-46-6 |
|
25 | 25 | 2.5 | >100 | >100 | >100 | >100 | >100 |
| 1,10-phenanthroline 66-71-7 |
|
>100 | 50 | 0.3 | 0.1 | 0.1 | 50 | 3 | 0.1 |