Table 8.
Summary of anti-bacterial activity and toxicity of compounds inspired by the natural products characterised in this project.
| Sample Name, structure and CAS no | Minimum Inhibitory/Toxicity Concentration of Drug (µM) | |||||||
|---|---|---|---|---|---|---|---|---|
| MRSA | E. coli | P. aeruginosa | M. tuberculosis H37Rv | HepG2 | HEK 293 | A549 | THP-1 | |
Hexylamine  111-26-2 |
>100 | >100 | 50 | >100 | >100 | >100 | >100 | >100 |
Dihexylamine  143-16-8 |
12.5 | 12.5 | 6.2 | >100 | >100 | 100 | >100 | >100 |
Dioctylamine  1120-48-5 |
6.2 | 6.2 | 3 | >100 | >100 | >100 | >100 | >100 |
Triethylamine  121-44-8 |
>100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
Tributylamine  102-82-9 |
>100 | >100 | 50 | >100 | >100 | >100 | >100 | >100 |
Trihexylamine  102-86-3 |
3 | 3 | 6.5 | >100 | >100 | 50 | 100 | >100 |
Trioctylamine  1116-76-3 |
12.5 | 25 | 25 | 0.02 | >100 | 6 | 50 | 3.1 |
Benzylamine  100-46-9 |
>100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
Dicyclohexylamine  101-83-7 |
>100 | >100 | 12.5 | >100 | >100 | >100 | >100 | >100 |
Dibenzylamine  103-49-1 |
>100 | >100 | 12.5 | >100 | >100 | >100 | >100 | >100 |
Tribenzylamine  620-40-6 |
>100 | >100 | 6.5 | >100 | >100 | >100 | >100 | >100 |
2,2′-Bipyridyl  366-18-7 |
>100 | >100 | >100 | 0.1 | 3 | 3 | >100 | 50 |
Isoquinoline  119-65-3 |
>100 | >100 | >100 | 0.1 | 3 | 3 | >100 | 50 |
Quinoline  91-22-5 |
>100 | >100 | >100 | 0.1 | 3 | 3 | 50 | 50 |
4,7-phenanthroline  230-07-9 |
1.5 | 1.5 | 2.5 | 2.5 | >100 | >100 | >100 | >100 |
1,7-phenanthroline  230-46-6 |
25 | 25 | 2.5 | >100 | >100 | >100 | >100 | >100 |
1,10 phenanthroline  66-71-7 |
>100 | 50 | 0.3 | 0.1 | 0.1 | 0.1 | 50 | 3 |
4,7-DImethyl-1,10-Phenanthroline  3248-05-3 |
0.3 | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
Neocuproine hemihydlyate  34302-69-7 |
0.09 | 0.3 | 0.04 | 0.1 | 0.1 | 0.1 | 6.2 | 12 |
5,6-Dimethyl-1, 10-phenanthroline  3002-81-1 |
0.3 | 0.78 | >100 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
3,4,7,8-Tetramethyl-1,10-phenanthroline  1660-93-1 |
0.3 | 0.3 | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
1,10-Phenanthroline-5,6-dione  27318-90-7 |
0.04 | 0.04 | 0.04 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
5-Nitro-1,10-phenanthroline  4199-88-6 |
0.09 | 0.78 | >100 | 0.1 | 0.1 | 0.1 | 12 | 0.1 |
Bathophenanthroline  1662-01-7 |
0.09 | 0.019 | 0.03 | 0.01 | 1.5 | 25 | 3 | 13 |
2,9-Dimethyl-1,7-diphenyl-1,10-phenatroline  4733-39-5 |
25 | 0.78 | 50 | 50 | 0.1 | 0.1 | >100 | >100 |
Bathocuproinedisulfonic acid sodium salt  1257642-74-2 |
>100 | >100 | 0.19 | 1.2 | 50 | 0.1 | >100 | >100 |