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. 2021 Mar 23;13(3):433. doi: 10.3390/pharmaceutics13030433

Figure 2.

Figure 2

(a) Schematic ternary phase diagram for an incongruently-dissolving CC. The three thick solid lines are the API solubility line, the CC solubility line, and the CF solubility line (from left to right). The thick dashed line indicates the CC solubility line in the metastable region. The thin solid lines indicate the phase boundaries, the thin dash-dotted line marks the CC stoichiometry. Dotted lines are the iso-RH lines at DRHCC, DRHCC/API, and the DRHCC/CF; (b) Schematic phase diagram showing the thermodynamically-stable phases for an incongruently-dissolving CC as function of the API/CF mass fraction in the dry system. Thick solid lines are deliquescence lines: API deliquescence, CC deliquescence line, and CF deliquescence line (from left to right). The thick dashed line indicates the CC deliquescence line in the metastable region. The thin solid lines indicate the phase boundaries, the thin dash-dotted line marks the CC stoichiometry. Dotted lines are the iso-RH lines at DRHCC, DRHCC/API, and the DRHCC/CF. The shaded region shows the presence of a liquid phase. The circles shown in (a,b) represent the equilibrium phases evolving at DRHCC.