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. 2021 Mar 23;13(3):433. doi: 10.3390/pharmaceutics13030433

Figure 3.

Figure 3

(a) Modeled ternary phase diagram of succinic acid/nicotinamide in mass fractions at 298.15 K. The SA solubility line starts from the left axis, the CC solubility line in the middle, and the NA solubility line starts from the right axis (cannot be seen in this diagram). The thin solid lines indicate the phase boundaries. The circles indicated solubility measurements obtained from the literature [26]; (b) Predicted phase diagram of succinic acid/nicotinamide showing the thermodynamically stable phases as function of the mass fraction in the dry system and RH at 298.15 K. The thick solid SA deliquescence line starts from the left axis intersecting the thick solid CC deliquescence line in the middle and the thick solid line of NA starts from the right axis (cannot be seen in this diagram). The thin solid lines indicate the phase boundaries, the thin dash-dotted line indicates the CC stoichiometry. Symbols indicate results of CC stability measurements after 49 days of storage. Triangles represent unchanged CC samples.