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. 2021 Mar 23;13(3):433. doi: 10.3390/pharmaceutics13030433

Figure 5.

Figure 5

(a) Predicted ternary phase diagram of carbamazepine/nicotinamide in mass fractions at 298.15 K. The CBZ hydrate solubility line starting from the left axis, the CC solubility line in the middle, and the NA solubility line starting from the right axis (lines are very close to the axis). The thin solid lines indicate the phase boundaries; (b) Predicted phase diagram of carbamazepine/nicotinamide showing the thermodynamically stable phases as function of the mass fraction in the dry system and RH at 298.15 K. The thick solid CBZ hydrate deliquescence line starting from the left axis intersecting the thick solid CC deliquescence line in the middle and the thick solid line of NA starts from the right axis (lines are very close to the axis). The thin solid lines indicate the phase boundaries, the thin dash-dotted line indicates the CC stoichiometry. Symbols indicate results of CC stability measurements after 49 days of storage. Triangles represent unchanged CC samples. The circle indicates deliquescence during storage.